Azelastine is a H1-antihistamine usable by local route, in nasal pulverization, in the treatment of allergic rhinitis.
H1-antihistamines are used for supportive care of allergic manifestations, cutaneous (urticaria) or mucous membranes (rhinitis, hayfever, conjunctivitis). Insufficient alone to treat anaphylactic shock or edema of the larynx, they could prevent them.
A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis.
Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
Cetirizine, carboxyl derivative of hydroxyzine which is used as a sedative and anxiolytic, in addition to its H1-antihistamine effect, inhibits release of various cytokines and leukotrienes.
In addition, each compound can have or not have parallel properties, antimuscarinic effects for example.
This distinction between generations must be taken with caution because a product considered as non sedative or not antimuscarinic can, in certain circumstances, large doses or particular susceptibility of the patient ,have these effects.
Mequitazine has an antimuscarinic effect parallel to its H1-antihistamine activity, which can result for example in dryness of mouth or accommodation disturbances.
Loratadine acts mainly via one of its metabolites, decarboethoxyloratadine, also called desloratadine, which is also marketed.